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These residues are located within the upper and central regions of the TM2 and TM3 bundle and have been recurrently associated with ligand recognition in active-state GLP-1R structures (Zhao et al., 2020)

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Genotype and Phenotype Correlations in 417 Children With Congenital Hyperinsulinism

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These advancements position microneedle technology as a transformative approach for delivering GLP-1 receptor agonists, offering the potential to improve therapeutic adherence, minimize systemic side effects, and support decentralized care models for diabetes management [43]

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